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. 2009 Feb 18;106(12):4882–4887. doi: 10.1073/pnas.0811648106

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Fig. 2. — Mecp2^S80A and Mecp2^S421A;S424A knock-in mice showed, respectively, decreased and increased locomotor activities. (A) Phospho-S80 antibody detected a band from brain extracts of wild-type mice, but not the Mecp2^S80A mice. The asterisk marks a nonspecific band. (B) Phospho-S421 antibody detected a band in normal wild-type mice brain extract, but not in brains of Mecp2^S421A;S424A mice. (C) Mecp2^S80A mice showed decreased locomotor activity when compared with their wild type littermates (n = 10 for wild type, n = 13 for S80A mutants, P = 0.029). Mecp2^S421A;S424A mice showed increased locomotor activity when compared with their wild type littermates (n = 14 for wild type, n = 15 for S421AS424A mutants, P = 0.014).