. Author manuscript; available in PMC: 2010 Feb 1.

Published in final edited form as: Brain Behav Immun. 2008 Aug 22;23(2):159–166. doi: 10.1016/j.bbi.2008.08.002

Table 1.

Summary of Effects of Psychosocial Interventions on Psychological, Neuroendocrine and Immune and Health Variables from Randomized Controlled Trials with Breast Cancer Patients

Study	Intervention Type	Intervention timing	Analyses	Sample (control condition)	Psychological variables	Neuroendocrine variables	Immune or Health Status
Andersen et. al., 2004	4 mo coping skills training, relaxation training and health education	Immediately after surgery, before adjuvant therapy	baseline to 4 months post	227 women with stage II/III breast cancer (Assessment only)	↓ Anxiety ↑ Social support	↑ T-cell proliferation to PHA and ConA	↑ Dietary habits ↓ Smoking
Andersen et. al., 2007	4 mo coping skills training, relaxation training and health education	Immediately after surgery, before adjuvant therapy	baseline to 4 months post	227 women with stage II/III breast cancer (Assessment only)			↑ Health status ratings
Antoni et al., 2006a, c	10 wk CBSM	≤8 weeks after surgery	baseline to 12 months post surgery	199 women with stage 0–III nonmetastatic breast cancer (1 day seminar)	↓ social disruption ↑ emotional well-being ↑ benefit finding ↑ positive states of mind ↓ thought intrusion ↓ emotional distress ↓ Interviewer ratings of anxiety		↑ Positive lifestyle change
McGregor et al., 2004	10 wk CBSM	≤8 weeks after surgery	Pre to post	34 women with stage I/II breast cancer (Wait-list control)	↑ Benefit finding	↑ LPR to anti-CD3
Savard et al., 2005	8 wk CBT	Mean 42 months post diagnosis	Pre to 3, 6, 12 mos post	57 women with newly diagnosed breast cancer	↑ Subjective sleep ↓ Depression ↓ Anxiety ↑ Global QOL	↑ in vitro IFN-γ & IL-1β production
Phillips et al. In press	10 wk CBSM	≤8 weeks after surgery	Pre, 6 and 12 mos post	128 women with stage 0–III nonmetastatic breast cancer	↑ perceived ability to relax	↓ Late afternoon serum cortisol