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. Author manuscript; available in PMC: 2009 Mar 23.
Published in final edited form as: Aging Cell. 2008 Dec;7(6):908–919. doi: 10.1111/j.1474-9726.2008.00440.x

Figure 3. Production of pro-inflammatory cytokines TNFα and IFNγ by T cell subsets isolated from CR and control male RM.

Figure 3

(A, B) percentage of CM and EM CD8 T cells that secrete IFNγ (A) or TNFα (B) in response to a 6 hr. in vitro stimulation with anti-CD3. In contrast to AO-CR, JO-CR results in increased prevalence of inflammatory cytokine-secreting memory T cells. (C, D) Percentage of CM and EM CD4 T cells that secrete IFNγ (C) or TNFα (D) in response to anti CD3 stimulation. JO-CR results in increased frequency of inflammatory cytokine-secreting CD4 T cells as well.