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Inhibition of PTP-1B with ISIS 113715 improves insulin sensitivity in obese, insulin-resistant rhesus monkeys. A, IVGTT results (insulin and glucose responses) from monkeys on the low-dose/dose-escalation regimen. B, IVGTT results (insulin and glucose responses) from monkeys on the high-dose regimen. Data are shown as mean ± sem (n = 15 for the low dose/dose escalation group and n = 5 for the high dose group).
