Fig. 3. Cytokines/hormones in angiogenesis.
Cytokines or hormones from adipocytes and macrophages are able to regulate angiogenesis. These include leptin, adiponectin, VEGF (vascular endothelial growth factor), TNF-α (tumor necrosis factor-alpha), MIF (macrophage migration inhibitory factor), IL-6 (interleukin-6), IL-8, PDGF (platelet-derived growth factor), TGF-β (transforming growth factor beta), and angiopoietin.
