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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Nat Genet. 2009 Feb 1;41(3):376–381. doi: 10.1038/ng.322

Figure 4. H3K36me3 is enriched across human and mouse exonic chromatin.

Figure 4

Average tag counts of middle exons after ChIP of (a) H3K36me3 (d) H3K4me3 from mouse MEF chromatin23 or (g) H3K36me3 (j) H3K4me3 (m) H3K27me1 from human CD4+ T cell chromatin22 across intron/exon and exon/intron boundaries where introns are at least 500bp and exons at least 200bp. In the gene model, thin grey lines represent 500bp intron sequence, black boxes 100bp exon sequence, and thick grey lines the centres of exons that vary in length. Mean ChIP tag counts across exons (b, e, h, k, n) or introns (c, f, i, l, o) for (b, c) mouse H3K36me3 (e, f) mouse H3K4me3 (h, i) human H3K36me3 (k, l) human H3K4me3 (n, o) human H3K27me1. Exons of length 350-450bp and introns of length 5-6kb were used, excluding the first 2kb of the gene to eliminate promoter specific signals. In diagrams below plots, black boxes represent exons and black lines introns.