Table 1.
Characteristics of the study population according to angiotensin-converting enzyme inhibitor use in men and women
| Variable | Men (n = 328) ACE Inhibitor |
Women (n = 417) ACE Inhibitor |
||
|---|---|---|---|---|
| Nonusers (n = 264) |
Users (n = 64) |
Nonusers (n = 32) |
Users (n = 96) |
|
| Total IGF-1 (ng/ml)* | 129 ± 55 | 147 ± 59‡ | 106 ± 52 | 117 ± 51† |
| Age (yrs)* | 73.1 ± 6.4 | 74.2 ± 7.4‡ | 74.2 ± 7.0 | 76.5 ± 6.5† |
| Body mass index (kg/m2)* | 27.1 ± 3.3 | 26.9 ± 3.3 | 27.6 ± 4.4 | 28.4 ± 4.9 |
| Caloric intake (kcal/d)* | 2,208 ± 560 | 2,091 ± 580‡ | 1,752 ± 470 | 1,720 ± 522 |
| Smoking (pack = yrs)* | 23.05 ± 23.0 | 25.3 ± 24.8† | 2.7 ± 8.0 | 3.1 ± 11.7 |
| Alcohol (g/d)* | 25.8 ± 27.6 | 19.2 ± 20.8 | 7.0 ± 9.5 | 6.7 ± 10.7 |
| Hemoglobin (g/dl)* | 14.5 ± 1.1 | 14.3 ± 1.3 | 13.3 ± 1.0 | 13.3 ± 1.1 |
| Creatinine clearance (ml/24 h)* | 86.3 ± 24.3 | 82.9 ± 25.7 | 69.7 ± 20.7 | 67.1 ± 24.3 |
| Physical activity | ||||
| Sedentary | 23 (8.7%) | 3 (4.9%) | 71 (23.0%) | 20 (22%) |
| Light | 235 (89.0%) | 57 (93.4%) | 237 (76.7%) | 70 (76.9%) |
| Moderate to high | 6 (2.3%) | 1 (1.6%) | 1 (0.3%) | 1 (1.1%) |
| Hypertension | 78 (37%) | 32 (50%) | 108 (41%) | 58 (60.4%)‡ |
| Cardiac heart failure | 4 (1.9%) | 9 (14.1%)‡ | 7 (2.6%) | 9 (9.4%)† |
| Stroke | 11 (5.3%) | 5 (8.0%) | 5 (2.0%) | 4 (4.2%) |
| Cancer | 12 (5.7%) | 3 (4.7%) | 25 (9.5%) | 7 (7.3%) |
| Diabetes mellitus | 26 (12.4%) | 6 (9.4%) | 25 (9.5%) | 10 (10.4%) |
| Total testosterone (ng/ml)* | 4.4 ± 1.3 | 4.2 ± 1.3† | 0.64 ± 0.30 | 0.63 ± 0.32 |
| Interleukin-6 (pg/ml) median (IQR) | 3.0 (2.0) | 3.4 (2.6) | 2.7 (1.7) | 2.7 (1.9) |
| Glutamic oxaloacetic transaminase (U/L)* | 21.9 ± 7.9 | 22.4 ± 6.9 | 20.5 ± 7.0 | 19.6 ± 6.8 |
| Glutamic pyruvic transaminase (U/L)* | 20.9 ± 11.9 | 21.8 ± 11.2 | 18.7 ± 11.4 | 18.0 ± 8.7† |
| No. of medications* | 1.5 ± 1.7 | 3.5 ± 2.1‡ | 1.9 ± 1.9 | 3.5 ± 1.8‡ |
*
Values are expressed as mean ± SD.
†
p <0.05 compared with nonusers of the same gender.
‡
p <0.001 compared with nonusers of the same gender.
IQR = interquartile range.