Table 4. Factors associated with acquisition of multidrug resistance in univariate and multivariate analyses.
| Cohort characteristics | Number of events | Person time in months | Univariate hazard ratio | P-value | Multivariate hazard ratio | P-value |
|---|---|---|---|---|---|---|
| Age | ||||||
| ≤ 40 | 7 | 2442 | 1.06 | 0.90 | 0.70 | 0.52 |
| > 40 | 8 | 2586 | ||||
| Gender | ||||||
| male | 11 | 2920 | 1.93 | 0.24 | 1.67 | 0.39 |
| female | 4 | 2108 | ||||
| Not-adherent | ||||||
| yes | 2 | 736 | 0.81 | 0.77 | 1.61 | 0.53 |
| no | 13 | 4267 | ||||
| Substance abuse | ||||||
| yes | 10 | 1944 | 2.88 | 0.04 | 1.96 | 0.26 |
| no | 5 | 3084 | ||||
| Side-effects | NI | |||||
| yes | 4 | 855 | 1.69 | 0.39 | ||
| no | 11 | 4173 | ||||
| Baseline cavity present | NI | |||||
| yes | 11 | 3432 | 1.25 | 0.69 | ||
| no | 4 | 1596 | ||||
| Previously incarcerated | NI | |||||
| yes | 3 | 656 | 1.56 | 0.51 | ||
| no | 12 | 4372 | ||||
| Smear ++ or +++ | NI | |||||
| yes | 4 | 1584 | 0.79 | 0.68 | ||
| no | 11 | 3444 | ||||
| Began treatment in hospitala | ||||||
| yes | 10 | 1703 | 3.8 | 0.01 | 6.34 | 0.02 |
| no | 5 | 3325 | ||||
| Hospitalized later during therapy only | ||||||
| yes | 13 | 2195 | 8.18 | < 0.001 | 6.26 | 0.047 |
| no | 2 | 2833 | ||||
| Self-administered treatment | NI | |||||
| yes | 2 | 1847 | 0.25 | 0.03 | ||
| no | 13 | 3181 |
a Individuals who were hospitalized at initiation of therapy as well as later were included only in the hospitalized at initiation category.