Figure 3.
Histone methylation after chronic amphetamine exposure. A, ChIP of striatal lysates found significantly more H3K9me2 bound to the c-fos promoter after 5 d of withdrawal from chronic amphetamine (*p < 0.05, Student's t test; n = 3), whereas no change occurred on the β-actin promoter. B, Rats treated with chronic amphetamine and analyzed after 5 d of withdrawal have significantly higher Kmt1a/Suv39h1 mRNA levels compared with saline-treated rats (*p < 0.05; n = 3), whereas Hdac5 levels remain unchanged (p > 0.05). Error bars indicate SEM.