Table 2.
Mean Volumes and SD of Total Hippocampus and Subfields in ccmm in Healthy Controls and Alzheimer's Disease
| Region | Total Control Population | Young Controls | Old Controls | AD | ||||
|---|---|---|---|---|---|---|---|---|
| Non-Apo e4 N = 43 |
Apo E4 N = 23 |
Non-Apo e4 N = 19 |
Apo E4 N = 9 |
Non-Apo e4 N = 24 |
Apo E4 N = 14 |
Non-Apo e4 N = 5 |
Apo E4 N = 10 |
|
| ERC | 205.5 (50.4) | 197.4 (55.7) | 221.3 (58.7) | 205.4 (54.1) | 193.0 (39.7) | 192.2 (58.1) | 120.4(34.6)# | 152.4 (56.5)# |
| Subiculum | 199.1 (36.1) | 192.0 (31.1) | 194.3 (37.9) | 195.6 (29.7) | 202.9 (35.0) | 189.6 (32.8) | 146.6 (28.2)# | 159.8 (504)# |
| CA1 | 346.9 (52.4) | 346.5 (50.0) | 371.7 (54.4) | 364.7 (28.6) | 327.2 (42.1) | 334.8 (57.9) | 287.2 (58.4)# | 261.3 (62.8)# |
| CA1-2 transition | 21.4 (6.0) | 19.2 (4.8) | 21.4 (7.2) | 17.8 (3.3) | 21.4 (5.1) | 20.1 (5.5) | 14.4 (2.3)# | 12.5 (2.6)# |
| CA3&DG | 236.2 (36.4)* | 215.9 (35.2) | 239.6 (35.6) | 223.6 (20.7) | 233.5 (37.5)* | 211.0 (42.1) | 253.0 (49.8)º | 205.0 (45.4) |
| Total Hippocampus | 5676.2 (726.5) | 5563.3 (826.3) | 5684.1 (749.5) | 5812.0 (623.3) | 5670.0 (723.9) | 5403.5 (919.8) | 5037.6 (747.8)# | 4351.0 (1379.3)# |
ERC, entorhinal cortex; CA1-2 transition, CA1-CA2 transition zone. SD, standard deviation
*
p <0.05 Apo e4 compared to non-Apo e4 of the same age group;
#
p <0.05 AD (Apo e4 and non Apo e 4 combined) compared to controls
º
p< 0.05 AD non Apo e4 with AD Apo e4 using Mann Whitney test using volumes normalized to intracranial volume