Skip to main content
. 2008 Nov 24;105(48):18976–18981. doi: 10.1073/pnas.0800466105

Fig. 3.

Fig. 3.

Histamine clearance is faster and inhibited more profoundly by OCT blockade in 5-HTT mutant mice than in WT mice. (A) Basal histamine T80 values were significantly faster in 5-HTT−/− and 5-HTT+/− mice than in 5-HTT+/+ mice. Shown is the reciprocal relationship between basal histamine and 5-HT T80 values, where 5-HT clearance is significantly longer in 5-HTT−/− mice than 5-HTT+/+ or 5-HTT+/− mice. ★, P < 0.05 and ★★, P < 0.01 vs. 5-HTT+/+ (1-way ANOVA with Tukey's post hoc comparisons). (B) Intrahippocampally applied D-22 (1.4 pmol) caused a robust percent increase in T80 values for histamine clearance over pre-D-22 baseline values in hippocampi of 5-HTT−/− and 5-HTT+/− mice but was without effect in 5-HTT+/+ mice. Data shown are mean and SEM for 2 min after injection of D-22. *, P < 0.05 compared to predrug baseline value (paired t test); ★, P < 0.05 compared with 5-HTT+/+ mice (1-way ANOVA with Tukey's post hoc comparisons).