FIG. 5.
BRG1 is required for typical chromatin structure after Th2 differentiation is complete. CD4+ lymph node cells were differentiated into Th2 cells in culture. Control or BRG1 RNAi was performed after Th2 differentiation was complete, as indicated. (a) BRG1 is required for the DNase I HS at RHS7, HSIV, IL-4 promoter, IL-4 3′ end, and GATA3 promoter a. (See also Fig. S8 in the supplemental material.) (b) BRG1 is required for histone acetylation in the Th2 locus. (See also Fig. S9 in the supplemental material.)