FIG. 3.
Sequence conservation and ER binding site distribution pattern in two cell types in relation to transcription start sites. (A) ERα binding site density in relation to the transcription start site. (B) Sequence conservation of all ERα binding sites in both cell types. Sequences flanking ERα binding regions are not conserved. (C) Sequence conservation of ERα binding sites that are unique to both cell types. Note the higher conservation of ERα binding sites in MCF-7p cells compared to MCF-7AKT cells (P < 10−16).