Table 3.
DRB1 allele frequencies observed in patients with PBC and healthy controls from the North, Center, and South of Italy. The prevalence (%) and number of homozygous (H) are listed for PBC and controls. P values before (P) and after correction for multiple testing (Pc) are indicated for each allele when <0.05. Only associations with uncorrected P values <0.05 are illustrated.
| DRB1 allele | Patients with PBC (%) | H(§) | Controls (%) | H(§) | P | Pc |
|---|---|---|---|---|---|---|
| NORTH | (n=301) | (n=903) | ||||
| *08 | 8.8 | 2 | 3.4 | 4*34−13 | 5.2*10−12 | |
| *11 | 13.6 | 8 | 26.3 | 50 | 3.9*10−8 | 4.6*10−7 |
| *13 |
7.3 |
2 |
11.9 |
4 |
5.7*10−6 |
0.000068 |
| CENTER | (n=171) | (n=513) | ||||
| *08 | 7.3 | 2.0 | 1*10−11 | 1.2*10−10 | ||
| *09 | 0.6 | 0.1 | 0.011 | |||
| *11 | 12.3 | 4 | 30.6 | 42 | 9.9*10−9 | 1.2*10−7 |
| *13 | 9.6 | 1 | 12.6 | 6 | 0.010 | |
| *14 |
10.2 |
1 |
5.6 |
|
0.013 |
|
| SOUTH | (n=192) | (n=576) | ||||
| *02 | 10.7 | 2 | 13.4 | 11 | 0.0033 | 0.039 |
| *07 | 18 | 8 | 10.8 | 6 | 0.019 | |
| *08 | 4.7 | 0.9 | 9.5*10−16 | 1.1*10−14 | ||
| *09 | 0.8 | 0.1 | 0.000075 | 0.00090 | ||
| *10 | 2.3 | 0.9 | 0.019 | |||
| *11 | 14.8 | 4 | 35.8 | 74 | 6.6*10−11 | 7.9*10−10 |
(§)
Number of homozygotes for alleles