Fig. 2.

Effects of nicotine (0.15, 0.3 and 0.6 mg/kg, s.c.) pretreatment on the mean (±SEM) number of cocaine infusions (% baseline) on a progressive ratio (PR) schedule of reinforcement obtained before 1 h of non-reinforcement (n=6). Asterisks denote a significant difference from saline treatment (P<0.05) and # denotes a significant difference from the highest dose of nicotine (0.6 mg/kg; P<0.05; Tukey’s HSD after one-way, repeated-measures ANOVA)