Fig. 2.
Recovery of depressed contractile function of diabetic cardiac myocytes after increased SERCA2a expression. A: typical recording of cell shortening of a cell from control mouse (SER-TG), a cell from a diabetic mouse (SER-TG diabetic), and a cell from a diabetic mouse after SERCA2a expression (SER-TG diabetic + DOX). B: depressed cell shortening in diabetic cardiac myocytes was returned to control values after SERCA2a expression. Depressed rate of contraction and relaxation (dL/dt) were also recovered after SERCA2a expression in the diabetic myocyte. L/LO, length-to-optimal length ratio. *P < 0.05 compared with SER-TG; †P < 0.05 compared with SER-TG diabetic. n = 60 cells from 3 hearts for each group.