FIG. 4.
Photomicrographs of pancreatic tissue sections. A: An NOD mouse pancreas 5 days after diabetes onset and before the start of treatments. Islets are infiltrated by leukocytes (dark blue-stained), and the few islets with remaining β-cells (brown-stained with insulin antibody) are surrounded and infiltrated by abundant leukocytes (inset a). B: An NOD mouse pancreas after treatment with vehicle for 3 weeks and an additional 3 weeks without treatment. Islets are heavily infiltrated by leukocytes and almost devoid of β-cells (inset b). C: An NOD mouse pancreas after treatment with 100 μg/kg GLP-1 and 1.5 μg/kg gastrin for 3 weeks and an additional 5 weeks without treatment. Islets with abundant insulin-stained β-cells are found, and some islets are surrounded by leukocytes, but most are not infiltrated and destroyed (inset c). (Please see http://dx.doi.org/10.2337/db08-0688 for a high-quality digital representation of this figure.)