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. 2008 Dec;57(12):3239–3246. doi: 10.2337/db08-0872

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Copyright © 2008, American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Resident M2a ATMs in lean mice are MGL1⁺ and are recruited independent of CCR2/CCL2. Immunofluorescence localization of ATMs in adipose tissue using confocal microscopy. Samples from male C57Bl/6 mice fed chow diet. Similar results were obtained from three to five independent mice. Bar = 50 μm. A: MGL1⁺ ATMs are present in interstitial spaces between adipocytes in multiple adipose tissue depots. Caveolin staining (red) delineates adipocytes. B: MGL1⁺ cells (red) are macrophages based on costaining with F4/80 (left panels) and CD11b (right panel). Images from epididymal fat pads. C: Perivascular localization of a portion of MGL1⁺ ATMs. Isolectin (red) labels endothelial cells to highlight vasculature in fat. MGL1⁺ ATMs express IL-10 (D) and CCR2 (E). F: MGL1⁺ ATMs are retained in epididymal adipose tissue from Ccl2⁻^/⁻ and Ccr2^−/− mice. (Please see http://dx.doi.org/10.2337/db08-0872 for a high-quality digital representation of this figure.)