Figure 8.
Hippocampus-dependent learning and memory impairments were evident in adult ES mice. A, Acquisition rate of Morris water maze learning (average of two trials/day) over 7 d. ES mice (n = 13) took significantly longer to find the hidden platform, compared with controls (n = 10; P < 0.05, two-way ANOVA). B, The ratio of time spent with a novel object vs. a familiar one, a measure of memory, was significantly lower in adult ES mice (n = 8), compared with controls (n = 6; *, P = 0.03, t test). C, Anxiety-like behavior was not more pronounced in adult ES (n = 13) vs. control (n = 10) mice. In the open field test, percent time spent in the center of the chamber was similar between groups (P > 0.05).