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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Eur J Pain. 2008 Mar 25;12(8):1078–1089. doi: 10.1016/j.ejpain.2008.02.002

Figure 4.

Figure 4

Representative samples of BOLD signal time courses related to six TSSP stimuli at 0.33 Hz (black lines) and 0.17 Hz (grey lines) of NC and FM subjects. VOIs: left rostral ACC; left THAL. Arrows indicate the duration of six heat stimuli at 0.33 Hz (black arrow) and 0.17 Hz (grey arrow). Residual brain activation after 0.33 Hz 6-pulse trains took more than twice as long to resolve as expected. In contrast residual brain activity after 0.17 Hz 6-pulse trains resolved within the expected time period. Similar BOLD time courses were observed at all VOIs. Signal intensity time courses were averaged across all significant voxels within statistically-identified clusters. TSSP: temporal summation of second pain; THAL: thalamus; BOLD: blood oxygen level dependent.