Figure 2. Spontaneous torpor bouts in leptin-deficient mice.
Six different ob/ob mice were implanted with temperature telemeters, allowed to recover for 10 days from the surgery, and housed individually at 20 °C. These mice were on a 12:12 light schedule, with the 12 hour dark cycle (D) commencing at the beginning of each day. These mice had free access to food and water during the duration of the 5 days of data collection. Each mouse entered a torpor bout at least once over the five days. On every day, at least two mice entered a spontaneous bout of torpor. Note the timing of entrance into torpor was typically near the end of the dark cycle, which was consistent across animals and across the different days.