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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Curr Opin Struct Biol. 2008 Jun 9;18(3):321–329. doi: 10.1016/j.sbi.2008.04.004

Figure 3.

Figure 3

Proposed multi-step mechanisms for the ligand-induced conformational transition in the aptamer domains of riboswitches. Shown are mechanisms based on fluorescence studies for (a) the C74U variant of the B. subtilis xpt-pbuX guanine riboswtich [13], (b) the Vibrio vulnificus adenosine deaminase riboswitch, and (c) the Escherichia coli thiamine pyrophosphate riboswitch [15], as well as NMR studies for (d) the B. subtilis xpt-pbuX guanine riboswitch [16••] and (e) the stem-loop IV thermosensor element from the repressor of heat-shock gene expression (ROSE).