FIG. 3.
Competitive growth of norB and tet38 mutants with wild-type strain MW2. The CI is defined as the mutant/wild-type output CFU ratio normalized by using the input CFU ratio. A CI of <1.0 indicates a mutant with a growth disadvantage compared to the wild type. Each open circle indicates a CI for either an abscess (in vivo) or a BHI culture (in vitro). The geometric mean of CIs for each group is indicated by a horizontal bar. Competition experiments were repeated separately at least three times for each group. Competition group A, MW2 norB versus MW2 in vivo; competition group B, MW2 norB versus MW2 in vitro; competition group C, MW2 tet38 versus MW2 in vivo; competition group D, MW2 tet38 versus MW2 in vitro; competition group E, MW2 norB geh::pSK950 versus MW2 geh::pSK950 in vivo; competition group F, MW2 norB geh::pSKnorB versus MW2 geh::pSK950 in vivo.