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Scope of SAL with trisaccharide-containing glycopeptides 2a–d.a
 | |||
|---|---|---|---|
| Entry | Glycopeptide(AA1) | Ligation Junction–AA2-AA1- | Isolated Ligation Yieldb |
| 1 | 2a (Gly) | Gly-Gly | 57% |
| 2 | 2b (Asp) | Gly-Asp | 70% |
| 3 | 2c (His) | Gly-His | 14% |
| 4 | 2d (Gly-Gly) | Gly-Gly | 44% |
Conditions: 4:1 v/v NMP:6M Gn·HCl, 1M HEPES, pH8.5, 2% PhSH, 37 °C, 96 h.
Isolated yield after HPLC purification.
