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. Author manuscript; available in PMC: 2008 Oct 30.
Published in final edited form as: Prog Nucleic Acid Res Mol Biol. 2006;81:179–229. doi: 10.1016/S0079-6603(06)81005-6

Fig. 8. Repair involved in the repair of Top1 covalent complexes in budding yeast.

Fig. 8

A. Schematic representation of the genetic pathways implicated in the removal of the Top1-DNA covalent complexes. Tdp1 appear to function in alternative pathways with Rad1/Rad10 and Slx1/Slx4. The other endonucleases (Mus81/Mms4; Mre11/Rad50/Xrs2 and Rad27) appear to function in parallel. Sae2 is a cofactor for the endonuclease activity of Mre11. Tpp1, Apn1 and Apn2 are 3′-phosphatases that remove the 3′-phosphate left after Tdp1 hydrolyzes the tyrosyl-DNA adduct (see Figs. 5B and 6C). B. Shematic representation of the sites of attack for Tdp1 and the endonucleases described in panel A. Srs2 helicase is also shown.