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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Apr 23;326(1):270–277. doi: 10.1124/jpet.108.138370

Figure 6.

Figure 6

Sequence alignment of Nav1.2, Nav1.4, Nav1.6, and Nav1.8 for segment 5 in domain I, segment 5 in domain II, and segment 6 in domain II. Three amino acids were selected in these areas because these amino acids are different in Nav1.8 from those in Nav1.2, Nav1.4, and Nav1.6 and are in trans-membrane regions close to the extracellular surface. The amino acids of Nav1.8 were introduced into Nav1.2 and Nav1.4, giving the single mutants: M271K, M900K, and M965T (Nav1.2 mutants), and M273K, M719K, and M784T (Nav1.4 mutants).