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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Apr 23;326(1):270–277. doi: 10.1124/jpet.108.138370

Figure 3.

Figure 3

Effects of ethanol (190 mM) and octanol (0.057 mM) on I–V curves of sodium currents in oocytes expressing Nav1.2 and Nav1.8. (A) Representative INa traces from oocytes expressing Nav1.2 in the absence and presence of ethanol or octanol. Currents were elicited by 50-ms depolarizing steps between −80 and 50 mV in 10-m V increments from holding potentials of −90 mV. (B) Effects of ethanol and octanol on representative I–V curves elicited from Vmax holding potential for Nav1.2. (C) Effects of ethanol and octanol on representative I–V curves elicited from V1/2 holding potential in oocytes expressing Nav1.2. (D) Representative INa traces in oocytes expressing Nav1.8 in the absence and presence of ethanol and octanol. (E) Effects of ethanol and octanol on representative I–V curves elicited from a Vmax holding potential in oocyte expressing Nav1.8. (F) Effects of ethanol and octanol on representative I–V curves elicited from a V1/2 holding potential in oocyte expressing Nav1.8.