Fig. 2.
Correlation of regional brain mu-opioid receptor (mOR) binding after one week or 12 weeks of enforced abstinence with time to relapse to cocaine use in 15 cocaine-dependent subjects (see Table 2). Brain regions (in red) showing a significant negative correlation after one week 1 (A) or 12 weeks (B) of abstinence. Color bar presents the T-scores. The axial plane is cut from 24 mm below the bicommissural plane at 4 mm intervals. Panels C and D show the relationship between mOR binding (Y axis) in the left orbitofrontal cortex (yellow arrow in A and B) after one week (C) or 12 weeks (D) of abstinence and log (time to relapse) (X axis). Each data point represents an individual subject.