TABLE 2.
Tracheal and cloacal titers of Dk/Laos/25/06 (H5N1) in domestic ducks immunized with the rg-WS/244 H5 influenza vaccine at different doses of HA protein
| Dose of HA protein (ng) | Virus titera
|
|||
|---|---|---|---|---|
| Trachea
|
Cloaca
|
|||
| 3 dpi | 5 dpi | 3 dpi | 5 dpi | |
| 1,000 | <b | < | < | < |
| 200 | 3.7 ± 1.3 (6/7) | 2.6 ± 1.7 (6/7) | 1.5 ± 1.1 (4/7) | 1.9 ± 0.7 (2/7) |
| 40 | 3.7 ± 0.7 (5/5) | 3.0 ± 1.1 (4/4) | 2.9 ± 0.7 (4/5) | 1.7 ± 0.3 (3/4) |
| 8 | 4.3 ± 1.0 (7/7) | 3.9 ± 0.5 (3/3) | 2.4 ± 1.1 (7/7) | 2.5 ± 0.4 (2/3) |
| 1.6 | 4.1 ± 1.7 (5/5) | 3.8 ± 1.6 (4/4) | 2.2 ± 0.8 (4/5) | 1.4 ± 1.4 (2/4) |
| 0.32 | 5.4 ± 0.8 (5/5) | 6.6 ± 0.2 (2/2) | 3.5 ± 1.0 (5/5) | 3.0 ± 0.7 (2/2) |
| Placebo | 5.6 ± 0.2 (6/6) | 4.8 ± 1.2 (5/5) | 2.5 ± 1.1 (5/6) | 2.6 ± 1.3 (5/5) |
a
Virus titers were determined in eggs and are expressed as the log10 EID50/ml. Data are presented as means ± standard deviations of titers of positive samples (≥0.75 log10 EID50/ml). The numbers of birds that shed virus are indicated in parentheses (number shedding/number tested). dpi, days postinfection.
b
<, the titer was below the limit of detection (<0.75 log10 EID50/ml).