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. 2008 Oct 7;105(41):15791–15796. doi: 10.1073/pnas.0804399105

Fig. 4.

Fig. 4.

Ca2+/Calmodulin, but not kinase activity, altered CaMKIIβ binding to F-actin. (A) Disruption of Ca2+/CaM binding decreased CaMKIIβ recovery from stable F-actin. Fluorescence recovery of GFP-CaMKIIβ after jasplakinolide and either 10-μM KN93, 10-μM KN92, or control treatment. (B) Half-maximal fluorescence recovery time and the unrecoverable fraction of GFP-CaMKIIβ after treatments as indicated. *, P < 0.05. The unrecoverable fraction of KN93 treatment approached significance from control, P = 0.059. (C) Fluorescence recovery of GFP-CaMKIIβ, GFP-CaMKIIβ-A303R, and GFP-CaMKIIβ-K43R. (D) Half-maximal fluorescence recovery times and the unrecoverable fraction for GFP-CaMKIIβ, GFP-CaMKIIβ-A303R, and GFP-CaMKIIβ-K43R.