TABLE VI.
Multivariable models that account for both host and viral factors provisionally associated with differential HIV-1 transmission from 429 index Zambians to their seronegative partners
| Models accounting for host and/or viral factorsa | Relative hazard (95% CI)b | Adjusted p | Odds ratio (95% CI) | Adjusted p |
|---|---|---|---|---|
| Reduced model | ||||
| A*36 | 1.71 (1.17–2.49) | 0.005 | 2.42 (1.21–4.85) | 0.013 |
| AgeΔ (per year) | 0.96 (0.94–0.99) | 0.008 | 0.95 (0.91–1.00) | 0.039 |
| GUIc | 2.23 (1.67–2.98) | <0.001 | 3.24 (2.10–5.00) | <0.001 |
| Viral load: highd | 2.41 (1.47–3.95) | <0.001 | 4.18 (2.19–7.98) | <0.001 |
| Viral load: mediumd | 1.78 (1.07–2.95) | 0.027 | 2.16 (1.13–4.11) | 0.020 |
| Full model | ||||
| A*36 | 1.74 (1.18–2.57) | 0.005 | 2.48 (1.19–5.17) | 0.016 |
| Cw*18 e | 0.75 (0.47–1.18) | 0.212 | 0.81 (0.43–1.53) | 0.521 |
| AgeΔ (per year) | 0.96 (0.94–0.99) | 0.007 | 0.96 (0.91–0.999) | 0.045 |
| GUIc | 2.24 (1.68–2.99) | <0.001 | 3.08 (1.97–4.83) | <0.001 |
| Viral load: highd | 2.24 (1.36–3.72) | 0.002 | 3.98 (2.05–7.71) | <0.001 |
| Viral load: mediumd | 1.73 (1.04–2.89) | 0.036 | 2.11 (1.10–4.07) | 0.025 |
a
Other putative factors tested earlier (Tables I–II and IV–V) drop out the final models (adjusted p >0.05).
b
Based on the Wilcoxon proportional hazards models.
c
In either index (initially seropositive) or nonindex (initially seronegative) partners.
d
Three categories of HIV-1 viral load in the index partners are defined as high (>105 copies/ml), medium (104–105), and low (<104, which serves as the reference group).
e
In tight LD with both B*57 (primarily B*5703) and B*81 (Table III).