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. 2008 Oct 20;183(2):297–311. doi: 10.1083/jcb.200803172

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© 2008 Tovey et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Potentiation of CCh-stimulated Ca²⁺ release by 8-Br-cAMP. (A and B) Ca²⁺ signals evoked by 1 mM CCh alone (black) or after prior treatment (red) with 8-Br-cAMP (A; 10 mM for 20 min) or PTH (B; 100 nM for 1 min). Results (n > 3 from one experiment; means ± SEM) are typical of more than six experiments. (C and D) Effects of 8-Br-cAMP, 8-Br-2′-O-Me-cAMP (C), and PTH (D) on peak [Ca²⁺]_i evoked by 1 mM CCh. (E) Effects of PTH (100 nM for 1 min) and 8-Br-cAMP (10 mM for 20 min) on CCh-evoked Ca²⁺ signals. (F) EC₅₀ values and maximal responses (as a percentage of control) are shown for CCh-evoked Ca²⁺ signals after the indicated treatments. Results (C–F) are means ± SEM from at least three experiments. (G) cAMP entirely mediates potentiation of CCh-evoked Ca²⁺ release.