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α2β1-mediated migration of K562 transfectant cells to the liver surface. K562 transfectant cells expressing α2β1 (KX2C2) or α2β1 variant lacking the α2 I-domain (KX2C2[I−]) were compared for their ability to reach the subcapsular region of the liver. In vivo videomicroscopy was carried out at 24 h after injection of 3 × 105 cells into nu/nu mice via a mesenteric vein. Results are presented as percentage of extravasated cells at the liver subcapsular region.
