Table I.
Summary of phenotypic changes in tetramer+ CD8 memory T cells
| Tet+a % |
FSC (MFI) |
CD25 % (MFI)b |
CD69 % |
CD45RA % |
CD45RO % |
CCR7 % (MFI) |
CD62L % |
||
|---|---|---|---|---|---|---|---|---|---|
| Patient 1 | |||||||||
| No stimc | 1.6 | (325) | 0 (5) | 0.8 | 88.5 | 67.8 | 0.1 (6) | 0.2 | |
| Stim | 4.2 | (491) | 98.2 (234) | 77.3 | 51.5 | 99.7 | 14.8 (25) | 3.5 | |
| Stim + TGF-β1 | 5.4 | (456) | 85.9 (156) | 72.6 | 39.9 | 99.1 | 79.1 (52) | 2 | |
| Patient 2 | |||||||||
| No stim | 1.6 | (317) | 0.3 (5) | 5.7 | 99.4 | 39 | 1.5 (13) | 1.4 | |
| Stim | 2.4 | (464) | 98.1 (426) | 56.3 | 48.6 | 99.7 | 8.9 (30) | 3.1 | |
| Stim + TGF-β1 | 3.8 | (416) | 54.1 (106) | 49.7 | 55.7 | 99.6 | 26.4 (38) | 0.7 | |
| Patient 3 | |||||||||
| No stim | 0.5 | (306) | 0.8 (6) | 51.3 | 97.6 | 91.6 | 6.0 (12) | 2.9 | |
| Stim | 2.1 | (466) | 100 (1352) | 42.4 | 20.3 | 99.5 | 77.1 (179) | 2.8 | |
| Stim + TGF-β1 | 3.2 | (477) | 99.9 (1347) | 48.6 | 20.4 | 99.8 | 99.1 (373) | 2.3 | |
a
Percent tetramer+ cells in CD8+ population.
b
Percent tetramer+ cells expressing surface marker; MFI is for the entire tetramer+ population.
c
Stim, stimulation.