Table 3.
Combined Effect* of LOC387715 Genotypes and Hemostatic Factors on the Risk of Age-Related Macular Degeneration (AMD)
| Any AMD
|
Early AMD
|
Late AMD
|
||||
|---|---|---|---|---|---|---|
| LOC387715 Genotype | Lower 2 Tertiles | Highest Tertile | Lower 2 Tertiles | Highest Tertile | Lower 2 Tertiles | Highest Tertile |
| Fibrinogen | ||||||
| G/G | 1.0 | 0.89 (0.59–1.35) | 1.0 | 0.94 (0.60–1.46) | 1.0 | 0.68 (0.28–1.67) |
| G/T + T/T | 1.79 (1.25–2.56) | 1.54 (0.98–2.43) | 1.75 (1.19–2.57) | 1.50 (0.92–2.45) | 1.90 (0.95–3.78) | 1.70 (0.73–3.97) |
| Homocysteine | ||||||
| G/G | 1.0 | 1.50 (0.99–2.29) | 1.0 | 1.30 (0.82–2.06) | 1.0 | 2.65 (1.15–6.12) |
| G/T + T/T | 2.13 (1.48–3.07) | 1.67 (1.05–2.67) | 1.95 (1.33–2.87) | 1.48 (0.89–2.46) | 3.42 (1.54–7.60) | 2.79 (1.12–6.93) |
| Plasminogen activator inhibitor 1 | ||||||
| G/G | 1.0 | 1.26 (0.78–2.04) | 1.0 | 1.18 (0.70–1.99) | 1.0 | 1.71 (0.63–4.60) |
| G/T + T/T | 1.67 (1.07–2.60) | 2.30 (1.31–4.02) | 1.47 (0.91–2.37) | 2.11 (1.17–3.83) | 2.65 (1.11–6.34) | 3.49 (1.15–10.59) |
| von Willebrand factor | ||||||
| G/G | 1.0 | 1.05 (0.64–1.70) | 1.0 | 1.10 (0.65–1.86) | 1.0 | 0.84 (0.30–2.38) |
| G/T + T/T | 1.81 (1.16–2.81) | 1.61 (0.93–2.80) | 1.63 (1.01–2.63) | 1.60 (0.89–2.90) | 2.67 (1.14–6.22) | 1.63 (0.57–4.70) |
Odds ratio (95% confidence interval).
*
All models adjusted for age and current smoking status.