Table 1.

We identified 205 Gli target genes in the limb that contained at least one Gli motif-containing binding region and performed de novo motif discovery using a GMS on all binding regions associated with these genes, dividing these into binding regions with a Gli motif and binding regions with no Gli motif. The table reports motifs with an enrichment value of ≥2 relative to matched genomic controls and a log ratio ≥500 (underlined). The table also indicates the relative enrichment in the other populations as well as in all GBRs that are not associated with limb genes. The numbers in parentheses indicate the total number of motifs discovered. Note that a few (35) Gli motifs are discovered in the limb targets with no Gli motif. This reflects differences in the Gli motif used for mapping, which we had discovered previously (Vokes et al. 2007) and the motif discovered in the limb. Gli⁺ GBRs refers to those containing Gli motifs, while Gli⁻ GBRs do not contain a Gli motif.