Table 4.
Comparison of disease characteristics between children with sepsis and purpura before and after the national meningococcal C vaccination campaign (July 2002)
| Before meningococcal C vaccinationa | After meningococcal C vaccinationa | |
| Total number of children (%) | 248 | 39 |
| (86.4) | (13.6) | |
| Case fatality (%) | 45b | 0b |
| (18.1) | (0) | |
| Age in years | 3.2 | 2.5 |
| (0.1 to 17.9) | (0.3 to 13.1) | |
| Number of children with DIC (%) | 186c | 20c |
| (79.5) | (62.5) | |
| Number of PICU-free days | 24c | 25c |
| (0 to 28) | (0 to 27) | |
| PRISM score | 15 | 20 |
| (1 to 44) | (2 to 37) | |
| Predicted death rate (%)d | 5.6 | 8.1 |
| (0 to 100) | (0 to 100) | |
| Base excess (mmol/L) | -7.7 | -8 |
| (-28 to 4.4) | (-18 to -2) | |
| Lactate (mmol/L) | 4.1 | 4.0 |
| Geometric mean, 95% CI | 3.8 to 4.4 | 3.3 to 4.8 |
| C-reactive protein (mg/L) | 93 | 84 |
| (6 to 326) | (25 to 334) | |
| Fibrinogen (g/L) | 2.5 | 3.2 |
| (0.2 to 6.8) | (0.3 to 6.4) | |
| Platelet count (×103/μL) | 110 | 135 |
| (13 to 475) | (25 to 227) | |
| Leukocytes (×103/μL) | 8.9 | 12.1 |
| Geometric mean, 95% CI | 7.9 to 10.0 | 9.4 to 15.6 |
| Glucose (mmol/L) | 5.7c | 7.2c |
| Geometric mean, 95% CI | 5.3 to 6.2 | 6.2 to 8.2 |
aResults represent median (min-max) unless stated otherwise. bp < 0.01. cp < 0.05. dPredicted death rate was based on the Rotterdam score. CI, confidence interval; DIC, disseminated intravascular coagulation; PICU, paediatric intensive care unit; PRISM, Paediatric Risk of Mortality.