Table 1.
Summary of the WRN mutations in the WS cell lines used in this study
| Cell line | Type | WRN mutation status | Codon | Exon | Nucleotide sequence | Mutation type |
|---|---|---|---|---|---|---|
| KO375 | LCL-EBV | Homozygous | 369 | 9 | CGA (Arg) to TGA (terminator) | Substitution |
| AG4103 | LCL-EBV | Homozygous | 369 | 9 | CGA to TGA | Substitution |
| JO1050 | LCL-EBV | Homozygous | 1047-78 | 26 | tag-GGT to tac-GGT (splice donor) | Substitution |
| AG9387 | LCL-SV | Wild type | ||||
| GM1310B | LCL-SV | Wild type | ||||
| SNW646 | LCL-EBV | Wild type | ||||
| HeLa | ST | Wild type |
Based on Yu et al. (1997). LCL, lymphoblastoid cell line; EBV, EBV transformed; SV, SV40 transformed; ST, spontaneous transformation.