Figure 6.
Adherens junctions are disrupted before tight and desmosomal junctions in response to HGF/SF. Unstimulated MDCK cells were costained for β-catenin (a) and ZO-1 (c) or for β-catenin (e) and desmoplakin (g). Costaining of cells treated with HGF/SF for 4 h with β-catenin (b) and ZO-1 (d) or with β-catenin (f) and desmoplakin (h) indicates that β-catenin is lost from intercellular junctions (e.g., arrow in b and arrowhead in f) where ZO-1 (d, arrow) and desmoplakin (h, arrowhead) are still present. Bar, 10 μm.