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. 2008 Sep 9;99(6):930–938. doi: 10.1038/sj.bjc.6604621

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Copyright © 2008 Cancer Research UK

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CXCL13 is the most strongly overexpressed chemokine in breast cancer tissue as compared with normal breast tissue. Using a real-time PCR-based and pathway-focused microarray analysis on tissue samples from 10 patients whose tumours had been surgically removed, we simultaneously analysed mRNA expression levels of 84 chemokines/cytokines and their receptors in malignant and autologous healthy breast tissue. All patients included were stratified according to their status of disease (T₂N₀M₀, stage II). (A) Dots represent mean expression of single genes in malignant and healthy tissues after normalisation for housekeeping gene 18S rRNA. Dotted lines indicate the arbitrary cutoff value of threefold over- or underexpression in malignant vs normal tissues. (B) The microarray analysis revealed 16 target genes that showed at least three times higher or lower mRNA expression levels in malignant than in autologous healthy breast tissue. Black columns represent genes upregulated in tumours and white columns indicate genes that were downregulated as compared with normal breast tissue.