Table 3.
Comparison of MMRpro-Based Probability With Leiden-Based Classification, Bethesda Guidelines, and Amsterdam Criteria*
| Carriers |
Noncarriers |
|||||
|---|---|---|---|---|---|---|
| MMRpro Pr ≥0.5 | MMRpro Pr <0.5 | MMRpro Pr ≥0.5 | MMRpro Pr <0.5 | Reclassification Rate, % | ||
| Leiden | ||||||
| ≥0.5 | 54 | 3† | 9 | 17‡ | ] | 33 |
| <0.5 | 39‡ | 22 | 23† | 80 | ||
| Bethesda Guidelines | ||||||
| + | 83 | 10† | 28 | 37‡ | ] | 24 |
| − | 1‡ | 18 | 4† | 63 | ||
| Amsterdam Criteria | ||||||
| + | 76 | 5† | 26 | 11‡ | ] | 15 |
| − | 17‡ | 23 | 6† | 89 | ||
Abbreviation: MMRpro Pr, MMRpro-based probability.
*
MMRpro and Leiden predictions dichotomized at 0.5 for illustrative purposes.
†
Patients classified differently using MMRpro, compared with the model in the corresponding row.
‡
Patients reclassified correctly using MMRpro.