Fig. 2.
Percent change in pial arteriolar diameter (±SD) during the 1st exposure to 3 and 10 μM ACh. Mice from different groups with common treatments and no drug inhibitors during the 1st ACh exposure were pooled into HO2+/+ cohorts without hemoglobin (Hb) transfusion (n = 12) and with Hb transfusion (n = 11) and into HO2-null (HO2−/−) cohorts without Hb transfusion (n = 6) and with Hb transfusion (n = 17). *Overall effect of mouse genotype (P < 0.01) by 2-way ANOVA with genotype as 1 factor and Hb transfusion as a second factor.