TABLE 1.
Expression of maturation markers in GFP-positive and -negative DC populations
| Virus | % Change in avg GMI relative to wt RSVa
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CD80
|
CD83
|
CD86
|
CD38
|
CD54
|
||||||
| GFP+ | GFP− | GFP+ | GFP− | GFP+ | GFP− | GFP+ | GFP− | GFP+ | GFP− | |
| ΔNS1 | 11 | 15c | 21 | 35 | −12 | 9 | 1 | 26 | 4 | 9 |
| ΔNS2 | −10 | 2 | −1 | 10 | −9 | −2 | 53c | 22 | 4 | 12 |
| ΔNS1/2 | 29c | 20c | 67c | 77b | 21 | 36b | 86c | 63c | 39c | 39c |
a
Values represent results from seven individual experiments using DC from different donors. For wt RSV, the average GMI values for the GFP+/GFP− populations were as follows: CD80, 59/41; CD83, 6/4; CD86, 61/34; CD38, 35/29; CD54, 440/320. Statistical analysis was performed using a one-way analysis of variance with Tukey's multiple comparisons test.
b
Significantly different from wt RSV (P < 0.01).
c
Significantly different from wt RSV (P < 0.001).