Fig. 5.
HCY alters calcium transients in myocytes by agonizing NMDA-R1. A: calcium transient properties for WT (n = 6), hyperhomocysteinemia (HHCY; n = 5), MK-801 + HHCY (n = 8) CsA + HHCY (n = 8), and GM-6001 + HHCY (n = 6) were determined. Data are means ± SE. P < 0.05 vs. WT (*) and vs. treatment groups (#). B: sample traces of calcium transient were recorded in WT and HHCY mice myocytes. A superimposed calcium transient trace is presented. Data were analyzed offline with IonWizard software from IonOptix.