Fig. 4.
HCY decreases myocyte mechanical function by activating NMDA-R1. Ventricular myocytes were field stimulated at 1-Hz pacing rate, and their mechanical properties were measured. %Cell shortening, maximal rate of contraction (−dL/dt), and maximal rate of relaxation (+dL/dt) were determined. Top left: cell shortening; top right: graphical presentation of %cell shortening; bottom, maximal rate of contraction (−dL/dt) and maximal rate of relaxation (+dL/dt). Values are means ± SE; n = 57–58 myocytes from 4–5 mice/group (n = 17–18 cells/group). P < 0.05 vs. WT mice (*) and vs. treatment groups (#).