Fig. 2.
Dexamethasone induced bcrp, p-glycoprotein (p-gp), and mrp2 protein expression in brain endothelial cells. A: representative Western blots demonstrating the concentration-dependent increase in protein expression of bcrp, p-gp, and mrp2 in primary endothelial cells when cultured with dexamethasone for 24 h. Quantitative analysis by densitometry of three different experiments is also shown. B: dexamethasone-induced increase in bcrp, p-gp, and mrp2 expression after incubation of endothelial cells with 250 nM dexamethasone was dependent on the time of exposure. Quantitative analysis by densitometry of three different experiments is also shown. *P < 0.05 vs. untreated cells, **P < 0.01 vs. untreated cells.