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Effects of OFQ on forced motor performance in mice
| Mice with motor impairment
|
||
|---|---|---|
| Proportion | Percent | |
| OFQ (i.c.v.) | ||
| Vehicle | 0/10 | 0 |
| 0.1 nmol | 0/20 | 0 NS |
| 0.3 nmol | 0/20 | 0 NS |
| 1 nmol | 5/20 | 25 NS |
| 3 nmol | 5/10 | 50 NS |
| Diazepam (p.o.) | ||
| Vehicle | 0/10 | 0 |
| 1 nmol/kg | 0/10 | 0 NS |
| 3 nmol/kg | 0/10 | 0 NS |
| 10 nmol/kg | 3/10 | 30 NS |
| 30 nmol/kg | 8/10 | 80† |
Motor performance was measured in a traction test as described. NS, not significant.
P < 0.05, Fisher exact probability test.
