Figure 2.
Effect of antisense on rat spatial memory. (A) ODNs were injected every 24 hr for 4 days before the first training day. Injections were continued during training every day. Rats were given three training trails each day for 4 consecutive days each trial lasting up to 120 s. Escape latency was measured by using a stopwatch. (B) Two days after training the island was removed, and the search strategy of the rat was monitored to determine whether the rat searched for the island in the quadrant where the island was located previously. (C) Distance of swimming in the first encounter with the pool. (D) Open-field exploratory behavior was monitored 1 day after the quadrant analysis in the same pool as the water maze but without water. All data are shown as means ± SEM.