Table 4.
GH pulsatility characteristics (sampling every 10 min, 1900 to 0700 h) in women with exercise-induced energy deficit, hypoleptinemia, and HA (n = 8) at baseline and after 2 wk of r-metHuLeptin treatment
| Variable (mean ± sd) | Euleptinemic controls (n = 6) | Women with exercise-induced chronic energy deficit and hypoleptinemia (n = 8)
|
|
|---|---|---|---|
| Baseline | Leptin × 2 wk | ||
| Basal secretion (ng/ml per 24 h) | 0.002 ± 0.001 | 0.01 ± 0.011 | 0.005 ± 0.007 |
| Half-duration (min) | 23.33 ± 10.85 | 31.12 ± 7.04 | 30.79 ± 5.58 |
| Half-life (min) | 11.40 ± 2.77 | 12.28 ± 5.41 | 13.17 ± 6.88 |
| Secretion events per 24 h | 8.67 ± 1.37 | 10.13 ± 2.03 | 11.13 ± 2.85 |
| Mean amplitude (ng/ml·min) | 0.317 ± 0.175 | 0.142 ± 0.066 | 0.187 ± 0.071 |
| Mean mass (ng/ml) | 6.56 ± 1.56 | 4.63 ± 2.03 | 5.94 ± 1.95 |
| Interpulse interval (min) | 82.22 ± 22.13 | 67.04 ± 15.62 | 63.78 ± 12.67 |
| Pulsatile (ng/ml per 24 h) | 56.82 ± 16.06 | 47.24 ± 25.59 | 68.69 ± 37.13 |
| Production (ng/ml per 24 h) | 58.55 ± 16.6 | 54.15 ± 28.57 | 72.51 ± 37.71 |
| Percent pulsatile (%) | 97.04 ± 0.52 | 87.43 ± 11.86 | 94.83 ± 7.96 |
| Mean concentration (ng/ml) | 1.31 ± 0.42 | 1.18 ± 0.55 | 1.69 ± 0.88a |
| AUC (ng/ml·min) | 962.9 ± 310.7 | 863.6 ± 401.2 | 1233 ± 645.2a |
| ApEn (1,20%) | 0.486 ± 0.190 | 0.708 ± 0.224 | 0.659 ± 0.179 |
| Random ApEn (1,20%) | 0.933 ± 0.218 | 1.32 ± 0.15 | 1.31 ± 0.16 |
GH pulsatility characteristics (sampling every 15 min, 1900 to 0700 h) in control euleptinemic women (n = 6) provided for reference, without statistical comparison due to different sampling frequency.
a
P = 0.05 vs. baseline.