FIG. 4.
Magnitudes of CD154+ CD4+ cytokine-producing T cells. The production of IFN-γ, IL-2, or TNF-α by CD154+ CD4+ T cells in groups A, B, and C after stimulation with Env-A, Env-B, and Gag antigens was measured. Data represent the median responses with interquartile ranges. For each antigen, data are shown for the baseline, 2 weeks after DNA administration, 2 weeks after each of the protein booster doses (Prot-1 and Prot-2), and closeout as five vertical bars on the x axis. The horizontal bars on the x axis represent all five time points for each antigen. Responses were significant (P < 0.05; Wilcoxon text) in all instances in which the interquartile range at baseline did not overlap with the median for the DNA, Prot-1, Prot-2, or study closeout time point.